Voici les joueurs de la semaine 16 dans la NFL pour les parties jouées les 25-28 décembre 2020.
AFC
OFFENSIVE: WR STEFON DIGGS, BUFFALO BILLS
DÉFENSIVE: CB MIKE HILTON, PITTSBURGH STEELERS
UNITÉS SPÉCIALES: K JASON SANDERS, MIAMI DOLPHINS
AFC – Joueurs de la Semaine
| Semaine | Offensive | Défensive | Unités Spéciales |
| 1 | QB Lamar Jackson, Baltimore | CB Casey Hayward, LA Chargers | K Daniel Carlson, Las Vegas |
| 2 | QB Josh Allen, Buffalo | LB TJ Watt, Pittsburgh | K Harrison Butker, Kansas City |
| 3 | QB Patrick Mahomes, Kansas City | CB Xavier Rhodes, Indianapolis | K Stephen Gostkowski, Tennessee |
| 4 | RB Joe Mixon, Cincinnati | DE Myles Garrett, Cleveland | K Brandon McManus, Denver |
| 5 | WR Chase Claypool, Pittsburgh | LB Patrick Queen, Baltimore | K Jason Sanders, Miami |
| 6 | RB Derrick Henry, Tennessee | DE Calais Campbell, Baltimore | K Brandon McManus, Denver |
| 7 | QB Baker Mayfield, Cleveland | DE Jerry Hughes, Buffalo | KR Byron Pringle, Kansas City |
| 8 | QB Patrick Mahomes, Kansas City | DE Stephon Tuitt, Pittsburgh | PR/KR Jakeem Grant, Miami |
| 9 | QB Josh Allen, Buffalo | DL Jeffery Simmons, Tennessee | K Nick Folk, New England |
| 10 | QB Ben Roethlisberger, Pittsburgh | S Jeff Heath, Las Vegas | LB E.J. Speed, Indianapolis |
| 11 | QB DeShaun Watson, Houston | DE Olivier Vernon, Cleveland | K Rodrigo Blankenship, Indianapolis |
| 12 | WR Tyreek Hill, Kansas City | LB AJ Klein, Buffalo | K Nick Folk, New England |
| 13 | QB Josh Allen, Buffalo | LB Kyle Van Noy, Miami | PR/WR Gunner Olszewski, New England |
| 14 | QB Lamar Jackson, Baltimore | CB Kenny Moore, Indianapolis | PR Diontae Spencer, Denver |
| 15 | QB Josh Allen, Buffalo | DT Deforest Buckner, Indianapolis | P Tommy Townsend, Kansas City |
| 16 | WR Stefon Diggs, Buffalo | CB Mike Hilton, Pittsburgh | K Jason Sanders, Miami |
NFC
OFFENSIVE: RB ALVIN KAMARA, NEW ORLEANS SAINTS
DÉFENSIVE: LB FRED WARNER, SAN FRANCISCO 49ERS
UNITÉS SPÉCIALES: P JOSEPH CHARLTON, CAROLINA PANTHERS
NFC – Joueurs de la Semaine
| Semaine | Offensive | Défensive | Unités Spéciales |
| 1 | QB Russell Wilson, Seattle | DE Ryan Kerrigan, Washington | P Thomas Morstead, New Orleans |
| 2 | QB Dak Prescott, Dallas | LB Micah Kiser, L.A. Rams | P Michael Dickson |
| 3 | QB Russell Wilson, Seattle | LB Shaquil Barrett, Tampa Bay | K Matt Prater, Detroit |
| 4 | QB Tom Brady, Tampa Bay | LB Za’Darius Smith, Green Bay | RB Mike Boone, Minnesota |
| 5 | QB Kyler Murray, Arizona | DL Aaron Donald, L.A. Rams | K Wil Lutz, New Orleans |
| 6 | QB Matt Ryan, Atlanta | S Budda Baker, Arizona | K Cairo Santos, Chicago |
| 7 | QB Kyler Murray, Arizona | LB Devin White, Tampa Bay | P Johnny Hekker, L.A. Rams |
| 8 | RB Dalvin Cook, Minnesota | LB Bobby Wagner, Seattle | K Ryan Succop, Kansas City |
| 9 | RB Dalvin Cook, Minnesota | LB Foyesade Oluokun, Atlanta | K Graham Gano, NY Giants |
| 10 | WR DeAndre Hopkins, Arizona | LB Leonard Floyd, L.A. Rams | K Matt Prater, Detroit |
| 11 | WR Robert Woods, L.A. Rams | DE Brian Burns, Carolina | P Tress Way, Washington |
| 12 | QB Kirk Cousins, Minnesota | DE Jacob Tuiti-Mariner, Atlanta | K Robbie Gould, San Francisco |
| 13 | QB Aaron Rodgers, Green Bay | DL Leonard Williams, NY Giants | K Dustin Hopkins, Washington |
| 14 | RB Cam Akers, L.A. Chargers | LB Haason Reddick, Arizona | P Tress Way, Washington |
| 15 | QB Kyler Murray, Arizona | LB Devin White, Tampa Bay | P Michael Dickson, Seattle |
| 16 | RB Alvin Kamara, New Orleans | LB Fred Warner, San Francisco | P Joseph Charlton, Carolina |
JOUEURS DU MOIS
AFC
| Mois | Offensive | Défensive | Unités Spéciales |
| Septembre | QB Josh Allen, Buffalo | LB TJ Watt, Pittsburgh | K Stephen Gostkowski, Tennessee |
| Octobre | RB Derrick Henry, Tennessee | DE Myles Garrett, Cleveland | K Jason Sanders, Miami |
| Novembre | QB Patrick Mahomes, Kansas City | LB TJ Watt, Pittsburgh | K Jason Sanders, Miami |
NFC
| Mois | Offensive | Défensive | Unités Spéciales |
| Septembre | QB Russell Wilson, Seattle | LB Lavonte David, Tampa Bay | P Jack Fox, Detroit |
| Octobre | QB Tom Brady, Tampa Bay | S Budda Baker, Arizona | P Johnny Hekker, L.A. Rams |
| Novembre | RB Dalvin Cook, Minnesota | DE Cameron Jordan, New Orleans | K Youghoe Koo, Atlanta |